On June 25, 2015, Cuevas Cordobes, Felix; Almansa-Rosales, Carmen; Garcia Lopez, Monica published a patent.Application of 40644-16-4 The title of the patent was Preparation of piperidine compounds as dual 蟽1 and 渭 opioid receptor modulators for treatment of pain. And the patent contained the following:
The invention relates to compounds of formula I having dual pharmacol. activity towards both the sigma (蟽1) and the 渭-opioid receptor and more particularly to piperidine compounds having this pharmacol. activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. I [wherein m is 1 or 2; V1, V2, or V3 is selected from N or C while the others are C; R1 is hydroxy, (un)substituted -C(O)NH2, (un)substituted aryl, etc.; R2 is H, halo, (un)substituted (cyclo)alkyl, etc.; R5 is H, halo, hydroxy, (un)substituted alkyl, etc.; W, X, Y, and Z are selected from C, N, or O and together with C-atom form a 5-membered heterocyclic ring which may be substituted at W, X, Y, or Z or is fused at W and X to a further ring system] or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof are claimed and exemplified. II was prepared via reductive amination of 1-phenyl-1H-1,2,3-triazole-4-carbaldehyde with N-(3-(piperidin-4-yl)phenyl)propane-2-sulfonamide hydrochloride carried out using the reductive agent, sodium triacetoxyborohydride. I were evaluated for dual 蟽1- and 渭-opioid binding activity using radioligand assays (data given). The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Application of 40644-16-4
The Article related to piperidine compound preparation sigma mu opioid receptor modulator pain, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 40644-16-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem