On November 15, 2017, Cook, James; Zusi, F. Christopher; Hill, Matthew D.; Fang, Haiquan; Pearce, Bradley; Park, Hyunsoo; Gallagher, Lizbeth; McDonald, Ivar M.; Bristow, Linda; Macor, John E.; Olson, Richard E. published an article.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one The title of the article was Design and synthesis of a novel series of (1’S,2R,4’S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor. And the article contained the following:
We describe an efficient and convergent synthesis of a series of (1’S,2R,4’S)-3H-4′-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2′-bicyclo[2.2.2]octanes], such as I (R = H, 5-Cl, 6-Me, etc.) displaying potency for the α7 nicotinic acetylcholine receptor (nAChR) and good selectivity vs. the related 5-HT3A receptor. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one
The Article related to azaspiro benzoimidazooxazole bicyclooctane preparation alpha 7 nicotinic acetylcholine receptor, 5-ht(3a) receptor, schizophrenia, spirooxazolines, α7 nicotinic acetylcholine receptor and other aspects.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem