Month: October 2022

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Synthetic Route of 250285-32-6.

Zhang, Zhi-Mao;Xu, Yu-Ting;Shao, Li-Xiong research published 《 Synthesis of N-heterocyclic carbene-Pd(II)-5-phenyloxazole complexes and initial studies of their catalytic activity toward the Buchwald-Hartwig amination of aryl chlorides》, the research content is summarized as follows. Three new N-heterocyclic carbene (NHC)-Pd(II) complexes using 5-phenyloxazole as the ancillary ligand was obtained in moderate to good yields by a one-pot reaction of the corresponding imidazolium salts, palladium chloride and 5-phenyloxazole under mild conditions. Initial studies showed that one of the complexes was an efficient catalyst for the Buchwald-Hartwig amination of aryl chlorides with various secondary and primary amines under the varied catalyst loading of 0.01-0.05 mol%, thus it will enriched the chem. of NHCs and gave an alternative catalyst for the coupling of challenging while cost-low aryl chlorides.

Synthetic Route of 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 1739-84-0, formula is C5H8N2, Name is 1,2-Dimethyl-1H-imidazole. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Related Products of 1739-84-0.

Zhang, Zexian;Luo, Guanyu;Zhou, Shiyuan;Zeng, Wenyan;Mei, Tao;Chen, Zihe;Yu, Xuefeng;Xiao, Xiang;Wang, Xianbao research published 《 Reasonably Introduced ZnIn₂S₄@C to Mediate Polysulfide Redox for Long-Life Lithium-Sulfur Batteries》, the research content is summarized as follows. In consideration of the inferior rate performance and low sulfur utilization of lithium-sulfur batteries (LSBs), an effective strategy via combining polar materials with the conductive carbon sulfur host is widely applied. Herein, metal organic framework-derived in situ-developed ZnIn₂S₄@C is innovatively synthesized to mediate lithium polysulfide (LPS) conversion based on high electron conductivity and strong chem. interactions for advanced LSBs. Polar ZnIn₂S₄ possesses strong chemisorption in keeping with the DFT calculation results and catalytic for LPSs, ensuring a high sulfur utilization. Meanwhile, the hollow non-polar carbon frame possessing hierarchical pores not only provides internal space to contain active species but also accommodates efficient electronic transferring and diffusion of lithium ions in the process of cycling. The above advantages make the electrode possess promising stability and good rate performances, achieving long-term and high-rate cycling. Thus, under a sulfur loading of 1.5 mg cm^-2, after 500 cycles, at 2 and 5 C, the as-prepared ZnIn₂S₄@C@S delivers reversible capacities of 734 mA h g^-1 (75.7% of the initial capacity with a dropping rate of 0.015% per cycle) and 504 mA h g^-1 (68.5% of the primal capacity with a dropping rate of 0.029% per cycle), resp. Even at a high sulfur loading of 5.0 mg cm^-2, at 5 C, 65.6% of the initial capacity can be maintained with a low fading rate of 0.430% per cycle after 500 loops with a high Coulombic efficiency of around 99.8%.

1739-84-0, 1,2-Dimethylimidazole is used in the synthesis of 1,2-dimethyl-3-n-butylimidazoliumchloride and 1,2-dimethyl-3-n-propylimidazolium chloride. It also can be used in the synthesis of 1-(2-methoxyethyl)-2,3-dimethylimidazolium chloride and hexafluorophosphate salts.
1,2-Dimethylimidazole is a heterocyclic compound that contains nitrogen and carbon. It can be produced by the reaction between glyoxal and fatty acid in the presence of a base. 1,2-Dimethylimidazole has been shown to have biological properties such as an antioxidant effect. It is also used as a chemical intermediate for production of other chemicals such as 2-methylimidazole and 3-methylimidazole. 1,2-Dimethylimidazole has been shown to react with metal carbonyls to produce methylimines, which are useful intermediates in organic synthesis. The reaction mechanism involves hydrogen bonding and steric interactions between the imidazole ring and the metal carbonyl reactant., Related Products of 1739-84-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Electric Literature of 250285-32-6.

Zhang, Yingying;Zhang, Rong;Ni, Chang;Zhang, Xue;Li, Yanji;Lu, Qingwen;Zhao, Yuxuan;Han, Fangwai;Zeng, Yongfei;Liu, Guiyan research published 《 NHC-Pd(II)-azole complexes catalyzed Suzuki-Miyaura cross-coupling of sterically hindered aryl chlorides with arylboronic acids》, the research content is summarized as follows. In order to synthesize hindered biaryls RR¹ [R = 2-MeC₆H₄, 2,6-di-EtC₆H₃, 2-Me-4-FC₆H₃, etc.; R¹ = Ph, 2-MeC₆H₄, 2-FC₆H₄, etc.], a series of NHC-Pd(II)-azole complexes I [R² = H, Me; R³ = H, Me; X = C, N] were synthesized and characterized. The steric environment effect as well as electronic effect of azole ligands had been assessed. All these complexes I were applied in the Suzuki-Miyaura cross-coupling reaction of sterically hindered aryl chlorides with low catalysts loadings (0.1 mol %) under mild conditions in air and good to excellent isolated yields of sterically hindered biaryls were obtained.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Electric Literature of 250285-32-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Related Products of 10111-08-7.

Zhang, Xin-Hui;Bo-Wang;Tao, Yuan-Yuan;Ma, Qin;Wang, Hao-Jie;He, Zhang-Xu;Wu, Hui-Pan;Li, Yi-Han;Zhao, Bing;Ma, Li-Ying;Liu, Hong-Min research published 《 Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents》, the research content is summarized as follows. A series of thiosemicarbazone derivatives I [R¹ = H, 4-MeO, 2-Br, 3-Br, 4-Br; R² = H, Me, 2-pyridyl, etc.; R³ = 2-furyl, 3-indolyl, 2-pyridyl, etc.; n = 0, 1, 2] containing different aromatic heterocyclic groups was synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds I showed improved antiproliferative activity against MGC803 cells. SAR studies revealed that compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] displayed significant advantages in inhibition effect with an IC₅₀ value of 0.031μM, and better selectivity between cancer and normal cells than 3-AP and DpC (about 15- and 5-fold improved resp.). Besides, compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] showed selective antiproliferative activity in not only other cancer cells but also different gastric cancer cell lines. In-depth mechanism studies showed that compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] could induce mitochondria-related apoptosis which might be related to the elevation of intracellular ROS level, and cause cell cycle arrest at S phase. Moreover, compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] could evidently suppressed the cell migration and invasion by blocking the EMT (epithelial-mesenchymal transition) process. Consequently, our studies provided a lead optimization strategy of thiosemicarbazone derivatives I which would contribute to discover high-efficiency and low-toxicity agents for the treatment of gastric cancer.

10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., Related Products of 10111-08-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Recommanded Product: 1H-Imidazole-2-carbaldehyde.

Zhang, Xiao-Min;Yin, Jiao;Gao, Hong-Ling;Cui, Jian-Zhong research published 《 Five new multinuclear rare earth complexes: Magnetism and near-infrared luminescence》, the research content is summarized as follows. Five new tri- and tetra-nuclear rare earth complexes utilizing a Schiff base ligand and co-ligand Hdbm were obtained: [Nd₃(dbm)₆(H₂L)₃]·3CH₃OH (1), [RE₄(dbm)₆(L)₂(CH₃OH)₃]·2CH₃OH (RE = Dy (2), Ho (3), Er (4), Yb (5)), (H₃L = N’-(2-carboxide-imidazole)-[(2-hydroxy-3-methoxyphenyl)methylene]hydrazide, Hdbm = 1,3-diphenyl-1,3-propanedione). Complexes 2–5 are centrosym. tetranuclear complexes with eight-coordinated RE^III ions, while complex 1 is a non-centrosym. trinuclear complex with nine-coordinated Nd^III ions, which could be caused by lanthanide contraction. The magnetic properties studies show that 2 exhibits representative single-mol. magnets behavior, leading to an energy barrier of 25.3 K as well as pre-exponential factor of 7.21 × 10^-7 s. Research on near-IR luminescence reveals that complexes 1, 3, 4 and 5 emit the characteristic emission peaks of the Nd^III ions, Ho^III ions, Er^III ions and Yb^III ions, resp. The luminescence lifetime and quantum yield of 5 are 1.39μs and 0.0695%, resp.

Recommanded Product: 1H-Imidazole-2-carbaldehyde, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Formula: C4H4N2O.

Zhang, Xiang;Dong, Xia;Lu, Weigang;Luo, Dong;Zhu, Xiao-Wei;Li, Xue;Zhou, Xiao-Ping;Li, Dan research published 《 Fine-Tuning Apertures of Metal-Organic Cages: Encapsulation of Carbon Dioxide in Solution and Solid State》, the research content is summarized as follows. Metal-organic cages are potential artificial models for mimicking biol. functions due to their capability of selective encapsulation for certain guest mols. In this work, authors designed and synthesized a series of rhombic dodecahedral Ni-imidazolate cages (Ni₁₄L₂₄) with precisely controlled aperture for CO₂ encapsulation. The aperture of the cages can be tuned by the strategies of ligand decoration and metal-ion hybridization. Similar to the breathing function of alveoli, CO₂ passes through the dynamic aperture into the cages under a pressure of 2.0-3.0 bar in methanol solution, and slowly move out of the cages when the pressure goes down. In the solid state, CO₂ is encapsulated and prisoned in the cages under a high pressure of 15.0-30.0 bar or supercritical conditions. By replacing the square-coordinated Ni²⁺ with Cu²⁺, the resulting Ni-Cu heteronuclear cage lost the capability of phys. encapsulating CO₂ even though the aperture’s size is only slightly changed.

Formula: C4H4N2O, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. COA of Formula: C27H37ClN2.

Zhang, Tao;Luan, Yu-Xin;Lam, Nelson Y. S.;Li, Jiang-Fei;Li, Yue;Ye, Mengchun;Yu, Jin-Quan research published 《 A directive Ni catalyst overrides conventional site selectivity in pyridine C-H alkenylation》, the research content is summarized as follows. Herein, application of bifunctional N-heterocyclic carbene-ligated Ni-Al catalyst in C3-H alkenylation of pyridines was described. This method overrode the intrinsic C2 and/or C4 selectivity, and provided a series of C3-alkenylated pyridines such as I in 43-99% yields and up to 98:2 C3 selectivity. This method not only allowed a variety of pyridine and heteroarene substrates to be used as the limiting reagent, but was also effective for the late-stage C3 alkenylation of diverse complex pyridine motifs in bioactive mols.

250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.

1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.

1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., COA of Formula: C27H37ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Safety of Imidazole-4-carbaldehyde.

Zhang, Shiyan;Yan, Ziqin;Li, Yafang;Gong, Yang;Lyu, Xilin;Lou, Jianfeng;Zhang, Daizhou;Meng, Xiangjing;Zhao, Yujun research published 《 Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells》, the research content is summarized as follows. Despite recent clin. progress in peptide-based dual inhibitors of MDM2/4, small-mol. ones with robust antitumor activities remain challenging. To tackle this issue, 31 (YL93) was structure-based designed and synthesized, which had MDM2/4 binding K_i values of 1.1 and 642 nM, resp. In three MDM4-overexpressing cancer cell lines harboring wild-type p53, 31 shows improved cell growth inhibition activities compared to RG7388, an MDM2-selective inhibitor in late-stage clin. trials. Mechanistic studies show that 31 increased cellular protein levels of p53 and p21 and upregulated the expression of p53-targeted genes in RKO cells with MDM4 amplification. In addition, 31 induced cell-cycle arrest and apoptosis in western blot and flow cytometry assays. Taken together, dual inhibition of MDM2/4 by 31 elicited stronger antitumor activities in vitro compared to selective MDM2 inhibitors in wild-type p53 and MDM4-overexpressing cancer cells.

Safety of Imidazole-4-carbaldehyde, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives.

Zhang, Qianqian;Yang, Shuang;Wang, Jun;Cheng, Jianwen;Zhang, Qiaoxin;Ding, Guoping;Hu, Yefa;Huo, Siqi research published 《 A DOPO based reactive flame retardant constructed by multiple heteroaromatic groups and its application on epoxy resin: curing behavior, thermal degradation and flame retardancy》, the research content is summarized as follows. A high-efficiency flame retardant composed of phosphaphenanthrene, benzothiazole and imidazole groups (PBI) was synthesized and served as flame retardant co-curing agent to reduce the fire hazard of epoxy resin (EP). The chem. structure of PBI was characterized by Fourier transform IR spectroscopy (FTIR), high-resolution mass spectroscopy (HR-MS), ¹H and ³¹P NMR. The curing behavior, thermal stability and flame retardant properties of the prepared EP systems were investigated. The curing behavior study disclosed that PBI accelerated the crosslinking reaction of EP and was chem. bonded with EP matrix to obtain intrinsic flame retardant thermoset. The resulting EP thermosets showed only slight decrease in glass transition temperature (T_g). The thermogravimetric anal. (TGA) results indicated both the catalytic decomposition and catalytic charring effects of PBI demonstrated by decreased thermal stability and enhanced charring capability of EP/DDS/PBI thermosets. The combustion test results showed remarkable improvement in the flame retardant properties of EP/DDS/PBI thermosets. When the phosphorus content was only 0.75 wt%, EP/DDS/PBI-0.75 thermoset achieved a limiting oxygen index (LOI) value of 34.6% and passed UL94 V-0 rating. Moreover, the peak of heat release rate (pk-HRR), average of heat release rate (average-HRR) and total heat release (THR) values were decreased by 48.7%, 31.1% and 28.3%, resp., in comparison with those of the EP/DDS thermoset. The flame retardant effect of PBI on EP was attributed to the catalytic charring effect to form protective char layer in condensed phase and release of free radicals with quenching effect and nonflammable gases with diluting effect in gaseous phase.

Category: imidazoles-derivatives, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Synthetic Route of 3034-50-2.

Zhang, Ling;Ge, Yu;Wang, Qing Ming;Zhou, Cheng-He research published 《 Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase》, the research content is summarized as follows. A series of imidazole flavonoids as new type of protein tyrosine phosphatase inhibitors were synthesized and characterized. Most of them gave potent protein phosphatase 1B (PTP1B) inhibitory activities. Especially, compound 11a(I) could effectively inhibit PTP1B with an IC₅₀ value of 0.63 μM accompanied with high selectivity ratio (9.5-fold) over T-cell protein tyrosine phosphatase (TCPTP). This compound is cell permeable with relatively low cytotoxicity. The high binding affinity and selectivity was disclosed by mol. modeling and dynamics studies. The structural features essential for activity were confirmed by quantum chem. studies.

3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Synthetic Route of 3034-50-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem