The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with an increase of the alkyl chain length of the alcohols. Formula: C27H37ClN2.
Zhou, Tongliang;Ma, Siyue;Nahra, Fady;Obled, Alan M. C.;Poater, Albert;Cavallo, Luigi;Cazin, Catherine S. J.;Nolan, Steven P.;Szostak, Michal research published 《 [Pd(NHC)(μ-Cl)Cl]2: Versatile and Highly Reactive Complexes for Cross-Coupling Reactions that Avoid Formation of Inactive Pd(I) Off-Cycle Products》, the research content is summarized as follows. In this study, air-stable NHC-Pd(II) chloro-dimers, [Pd(IPr)(μ-Cl)Cl]2 (IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), as the most reactive Pd(II)-NHC catalysts developed to date were established. Most crucially, compared with [Pd(IPr)(allyl)Cl] complexes, replacement of the allyl throwaway ligand with chloride allows for a more facile activation step, while effectively preventing the formation of off-cycle [Pd2(μ-allyl)(μ-Cl)(IPr)2] products. The utility is demonstrated via broad compatibility with amide cross-coupling, Suzuki cross-coupling, and the direct, late-stage functionalization of pharmaceuticals. Computational studies provide key insight into the NHC-Pd(II) chloro-dimer activation pathway. A facile synthesis of NHC-Pd(II) chloro-dimers in one-pot from NHC salts is reported. The tremendous utility of Pd-catalyzed cross-coupling reactions and the overwhelming success of [Pd(IPr)(allyl)Cl] precatalysts, NHC-Pd(II) chloro-dimers, and [Pd(IPr)(μ-Cl)Cl]2, which should be considered as go-to precatalysts of choice in cross-coupling processes, were believed.
250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.
1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Formula: C27H37ClN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem