Imidazole based anticancer drug find applications in cancer chemotherapy. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Quality Control of 250285-32-6.
Zhao, Chao-Yang;Ji, Ding-Wei;Zheng, Hao;He, Gu-Cheng;Liu, Heng;Hu, Yan-Cheng;Chen, Qing-An research published 《 Pd-Catalyzed Redox Divergent Coupling of Ketones with Terpenols》, the research content is summarized as follows. A Pd-catalyzed redox divergent coupling of ketones e.g., 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one with terpenols like trans-geraniol, (E,E)-farnesyl alc. and (E)-phytol has been developed to access α-substituted ketones, e.g., 6-isopentyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one with varying degrees of unsaturation The control of oxidation states of the product is facilitated by employing different additives. With the aid of BnOH as an external hydrogen source, a reductive coupling pathway is thermodynamically favored. The use of LiBr as the additive will reduce the reactivity of Pd-H to divert the selectivity toward α,β-unsaturated ketones. By switching the solvent from toluene to chlorobenzene, the active species Pd-H will be fully quenched to enable oxidative coupling. Gram-scale reaction with lower catalyst loading (0.5 mol%) was also accomplished to highlight the practicability of this protocol. Furthermore, detailed exptl. studies were carried out to elucidate the reaction mechanism and the factors enabling manipulation of the redox selectivity. This redox divergent coupling protocol provides an important complement for known precedents on Tsuji-Trost allylation of ketones.
250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.
1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Quality Control of 250285-32-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem