Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Electric Literature of 250285-32-6.
Zhang, Yingying;Zhang, Rong;Ni, Chang;Zhang, Xue;Li, Yanji;Lu, Qingwen;Zhao, Yuxuan;Han, Fangwai;Zeng, Yongfei;Liu, Guiyan research published 《 NHC-Pd(II)-azole complexes catalyzed Suzuki-Miyaura cross-coupling of sterically hindered aryl chlorides with arylboronic acids》, the research content is summarized as follows. In order to synthesize hindered biaryls RR1 [R = 2-MeC6H4, 2,6-di-EtC6H3, 2-Me-4-FC6H3, etc.; R1 = Ph, 2-MeC6H4, 2-FC6H4, etc.], a series of NHC-Pd(II)-azole complexes I [R2 = H, Me; R3 = H, Me; X = C, N] were synthesized and characterized. The steric environment effect as well as electronic effect of azole ligands had been assessed. All these complexes I were applied in the Suzuki-Miyaura cross-coupling reaction of sterically hindered aryl chlorides with low catalysts loadings (0.1 mol %) under mild conditions in air and good to excellent isolated yields of sterically hindered biaryls were obtained.
250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.
1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., Electric Literature of 250285-32-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem