Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Electric Literature of 60-56-0.
Zhang, Cheng;Shao, Congying;Wang, Junsheng;Li, Ziwei;Liang, Mengna;Wang, Yongxiang;Liu, Dan;Lu, Shun research published 《 Multifunctional Fluorescent Copper Nanoclusters for Ag+ Sensing, Anticounterfeiting, and Blue/White Light-Emitting Diodes》, the research content is summarized as follows. Copper nanoclusters (CuNCs) with bright blue-emitting fluorescence have been synthesized via a simple one-pot process using 2-mercapto-1-methylimidazole (MMI) as a stabilizer. The as-prepared MMI-CuNCs exhibited a high quantum yield of 19.2%, a long luminescence lifetime of 10.57μs, and excellent photostability. Significantly, the fluorescence intensities of MMI-CuNCs were effectively quenched with addition of Ag+ ions, and the MMI-stabilized CuNCs were developed as a sensitive fluorescent nanoprobe for the label-free determination of silver ions for the first time. The fluorescence sensor provided a fast linear response toward Ag+ in the range of 0.025-50μM, with a detection limit of 6.7 nM. The fluorescence quenching mechanism was ascribed to an agglomeration-induced effect and static quenching. A fluorescence sensing platform was successfully applied for Ag+ detection in human serum samples with good accuracy and high reproducibility, signifying the practical applicability of the assay. Addnl., MMI-CuNCs displayed good solid-state blue emission and are suitable for security ink applications. The MMI-CuNCs were utilized as a color conversion layer to construct blue- and white-light-emitting diodes (LEDs) with excellent white light properties by a facile combination of MMI-CuNCs and UV LED chips. This result facilitates multiple functions of MMI-CuNCs in the application of label-free sensors, anticounterfeiting, and optical devices.
60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., Electric Literature of 60-56-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem