Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 250285-32-6, formula is C27H37ClN2, Name is 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . SDS of cas: 250285-32-6.
Tsuda, Susumu;Asahi, Kaoru;Takahashi, Ryota;Yamauchi, Hiroki;Ueda, Ryoji;Iwasaki, Takanori;Fujiwara, Shin-ichi;Kambe, Nobuaki research published 《 Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes》, the research content is summarized as follows. Chiral aralkyl alcs. RCH(OH)Ar1 were prepared by asym. arylation of aldehydes RCHO (R = substituted Ph, 2-naphthyl, 2-furyl, Bu) with arylboronic acids Ar1B(OH)2 (Ar1 = substituted P, 2-naphthyl, benzodioxolyl) catalyzed by in situ-formed rhodium self-inclusion NHC-cyclodextrin conjugated complexes. Reaction of 6-O-tosyl-substituted α- and γ-cyclodextrins with 1-Me and 1-mesityl-substituted imidazoles afforded imidazolium proligands Im-CD (L1-L4), which, upon reaction with Rh2(OAc)4 catalyze asym. arylation of the aldehydes RCHO. Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widespread interest in incorporating enzymic behavior into transition-metal catalytic systems that highly efficiently produce enantiopure compounds Nevertheless, bio-inspired transition-metal catalysts that are highly enantioselective and reactive have rarely been reported. In this study, we applied γ-cyclodextrin-imidazolium salts to the rhodium-catalyzed asym. arylations of aldehydes. The method exhibits wide substrate scope and the corresponding arylcarbinols are obtained in excellent yields under optimized conditions, with enantiomeric excesses of up to 96% observed Kinetic and competition experiments revealed that self-inclusion of the Rh complex contributes to the high enantioselectivity and reactivity achieved by this catalytic system. Thus, this bio-inspired self-inclusion strategy is promising for the development of highly enantioselective and reactive transition-metal catalysts for asym. carbon-carbon bond formation.
SDS of cas: 250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, also known as 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride, is a useful research compound. Its molecular formula is C27H37ClN2 and its molecular weight is 425 g/mol. The purity is usually 95%.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride has been used to generate N-heterocyclic carbene catalysts for use in carbonylative cross-coupling of pyridyl halides with aryl boronic acids.
1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is an imidazolium salt that is active against all stages of Trypanosoma cruzi and may represent a promising candidate for treatment of Chagas disease.
1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is an organic compound that is used as a solvent. It was originally synthesized by reacting triethyl orthoformate with 2,6-diisopropylaniline. This reaction formed the corresponding imidazolium salt. The synthesis of this compound was later improved by using ring-opening polymerization of glycolide and furfural. 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is mainly used to extract estradiol from urine samples in clinical laboratories., 250285-32-6.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem