Imidazole based anticancer drug find applications in cancer chemotherapy. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). Application of C4H4N2O.
Tanaka, Tsubasa;Sunatsuki, Yukinari;Suzuki, Takayoshi research published 《 Iron(II) Complexes Having Dinuclear Mesocate or Octanuclear Bicapped Trigonal Prism Structures Dependent on the Rigidity of Bis(bidentate) Schiff Base Ligands Containing Imidazole Groups》, the research content is summarized as follows. Dinuclear complex, [Fe2(H2L1,Me)3](ClO4)4 (1Me, H2L1,Me = N,N’-(1,3-phenylene)bis(1-(5-methyl-1H-imidazol-4-yl)methanimine)), and octanuclear complexes, [Fe8(H2L2,Me)12](ClO4)16 (2HClO4: H2L2,Me = N,N’-(1,3-phenylenebis(methylene))bis(1-(1H-imidazol-4-yl)methanimine)) and [Fe8(H2L2,Me)12](X)16 (2MeX: H2L2,Me = N,N’-(1,3-phenylenebis(methylene))bis(1-(5-methyl-1H-imidazol-4-yl)methanimine), X = ClO4, BF4), were synthesized. It was revealed by x-ray anal. that 1Me has a dinuclear mesocate structure. However, 2HClO4 and 2MeX have novel octanuclear bicapped trigonal prism structures with six Fe(II) sites having the meridional configuration on vertexes and two Fe(II) sites having the facial one on the centers of each triangular base. Magnetic susceptibility studies indicated that these dinuclear and octanuclear complexes show gradual spin-crossover (SCO) behavior.
Application of C4H4N2O, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem