Imidazole based anticancer drug find applications in cancer chemotherapy. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC). COA of Formula: C4H4N2O.
Sigalov, Mark V.;Shainyan, Bagrat A.;Chipanina, Nina N.;Oznobikhina, Larisa P.;Sterkhova, Irina V. research published 《 Photoisomerization and hydrogen-bonding-induced association in 2-(1H-diazol-2-ylmethylene)indane-1-ones and 2-(1H-diazol-2-ylmethylene)-1H-indene-1,3(2H)-diones.》, the research content is summarized as follows. The products of condensation of 2-imidazolyl-, 4-imidazolyl-, 3-pyrazolylcarbaldehydes with indan-1-one 1-3 and 1H-indene-1,3(2H)-dione 4-6 were synthesized. The E-isomers of 1-3 undergo UV-induced isomerization to the Z-isomers stabilized by intramol. NH···O=C hydrogen bond with the pyrrolic-type NH group. Theor. anal. of all isomers, tautomers and rotamers showed that the degree of conjugation between the diazolyl group and the C=O group decreases in the order 1 > 2>3. Spectroscopic study of 1-6 performed before and after UV irradiation allowed to conclude on the nature of the associates formed. A remarkably different association of the 2- and 4-imidazolyl derivatives 4 and 5 was revealed by X-ray and confirmed theor., leading to the formation of the chelate rings closed by NH···O=C hydrogen bond in 4 or by N-H …Npyridinic hydrogen bond in 5. Both chelate rings include two bifurcate H-bonds with bifurcation on the carbonyl oxygen and the pyrrolic NH hydrogen.
COA of Formula: C4H4N2O, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem