Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Reference of 10111-08-7.
Shang, Junfeng;Li, Yuxin;Yang, Na;Xiong, Lixia;Wang, Baolei research published 《 Synthesis and evaluation of novel 1-(((6-substituted benzo[d]thiazol-2-yl)amino)(heteroaryl)methyl)naphthalen-2-ol as pesticidal agents》, the research content is summarized as follows. To discover new agrochems. with prominent pesticidal properties, a series of novel β-naphthol derivatives containing benzothiazolylamino and various heteroaryl groups I (R = H, CF3, Cl; Het = pyrazol-5-yl, imidazol-2-yl, pyrimidin-5-yl, etc.) were efficiently synthesized via Betti reaction. The bioassay results showed that most of the synthesized compounds exhibited favorable insecticidal potentials, particularly towards oriental armyworm (50-100% at 200 mg·L-1) and diamondback moth (50-95% at 10 mg·L-1). Some compounds possessed LC50 values of 0.0988-5.8864 mg·L-1 against diamondback moth. Compounds I (R = H; Het = 2-phenyl-2H-1,2,3-triazol-4-yl), I (R = H; Het = 6-chloroimidazo[1,2-a]pyridin-3-yl), I (R = H; Het = 6-bromoimidazo[1,2-a]pyridin-3-yl) also displayed lethality rates of 30-90% against spider mite at the concentration of 100 mg·L-1. Overall, some compounds could be considered as new insecticidal/acaricidal leading structures for further investigation. The calcium imaging experiments revealed that compound I (R = H; Het = 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl), I (R = H; Het = 2-phenyl-2H-1,2,3-triazol-4-yl), and 1-((benzo[d]thiazol-2-ylamino)(4-methoxyphenyl)- Methyl)naphthalen-2-ol could activate the release of calcium ions in insect (M. separata) central neurons at a higher concentration (50 mg·L-1). The SAR anal. provided valuable information for further structural modifications.
Reference of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem