Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. 10111-08-7, formula is C4H4N2O, Name is 1H-Imidazole-2-carbaldehyde. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Application In Synthesis of 10111-08-7.
Regnault, Romain;Kouach, Mostafa;Goossens, Laurence;Thuru, Xavier;Bailly, Christian;Goossens, Jean-Francois research published 《 Mono- and bis-edaravone adducts formed in the presence of vanillin in an aqueous solution》, the research content is summarized as follows. Edaravone (EDA) is an antioxidant drug used for the treatment of amyotrophic lateral sclerosis. Edaravone has been shown to react with aldehydes, such as 6-formylpterin. We investigated the reaction of edaravone with vanillin (used as a model aromatic aldehyde) to evidence the reaction products formed in an aqueous solution Mono- and bis-adducts vanillin-(edaravone)1-2 were characterized by high-performance liquid chromatog. coupled to high-resolution mass spectrometry. Kinetic anal. revealed that the bis-adduct vanillin-(edaravone)2 formed more intensely and more rapidly than the mono-adduct vanillin-(edaravone)1. Decay rates of 2.4μM/min and 3.4μM/min were calculated for vanillin and edaravone, resp. The Michael addition of a second edaravone mol. onto the vanillin-(edaravone)1 hybrid corresponds to a facile reaction compared to the initial Knoevenagel-type condensation between edaravone and vanillin. However, the bis-adduct vanillin-(edaravone)2 can decompose in solution to provide the mono-adduct and regenerate small amounts of edaravone and vanillin. The regeneration of vanillin from vanillin-(edaravone)2 was kinetically characterized. We compared the condensation of edaravone with fifteen aromatic aldehydes, to show that only vanillin and 3-methoxy-benzaldehyde can react easily with edaravone, the other aromatic aldehydes being less or not reactive. The study opens perspectives to apprehend the reactivity of edaravone with biol. relevant aldehydes.
Application In Synthesis of 10111-08-7, 1H-Imidazole-2-carbaldehyde, also known as 1H-Imidazole-2-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
1H-Imidazole-2-carboxaldehyde is a novel PTP1b inhibitor with potential application to treat type 2 diabetes.
1H-Imidazole-2-carboxaldehyde is a broad-spectrum antimicrobial that has been shown to inhibit the growth of bacteria by interfering with protein synthesis. It binds to the cytosolic protein and receptor molecule, which are involved in the activation of bacterial enzymes. Imidazole-2-carboxaldehyde reacts with anhydrous sodium and copper complex to produce hydrogen bonds, which prevent the formation of the nitrogen atoms necessary for cellular processes. This chemical also has biological properties such as glyoxal, which inhibits bacterial growth by reacting with amino groups on proteins., 10111-08-7.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem