Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. Their solubility in alcohol is lower than that in water and decreases with increasing molecular weight of the alcohols . Quality Control of 3034-50-2.
Panchani, Nayankumar M.;Joshi, Hitendrakumar S. research published 《 A facile, efficient and catalyst free synthesis of imidazole, tetrazole and pyrimidine combined moiety as potential antimicrobial and antitubercular agents》, the research content is summarized as follows. A synthesis of 5-(substituted-phenyl)-7-(1H-imidazol-4-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine derivatives I [R = H, 4-Me, 4-Cl, etc.] was described by reaction of chalcones II with 5-aminotetrazole without catalyst in appropriate solvent. The structural elucidation of these compounds was based on MS, IR, 1H-NMR and 13C-NMR spectral data. The in vitro antimicrobial activity was investigated against Gram-pos. and Gram-neg. bacterial and fungal strains. It was found that the compounds I [R = 4-Cl, 4-Br, 4-Me, 4-OH] showed significant activities against tested organisms as compared to standard drugs (Ampicillin and Griseofulvin) while compounds I [R = 4-Cl, 4-Me, 4-F, 3-NO2] showed good percentage of average inhibition in the dormant and active stage of tuberculosis.
3034-50-2, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, Quality Control of 3034-50-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem