Imidazole Biochem/physiol Actions: Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Safety of Imidazole-4-carbaldehyde.
Nguyen, Hai Truong;Le, Tan Van;Tran, Phuong Hoang research published 《 AC-SO3H/[CholineCl][Urea]2 as a green catalytic system for the synthesis of pyrano[2,3-c]pyrazole scaffolds》, the research content is summarized as follows. A sulfonated amorphous carbon (AC-SO3H) was prepared from rice husk with sulfuric acid and fully characterized using FT-IR spectroscopy, X-ray diffraction (XRD), SEM (SEM), energy-dispersive X-ray spectroscopy (EDS). Deep eutectic solvent between choline chloride and urea was obtained from cheap and available material. The as-synthesized AC-SO3H was applied to prepare pyrano[2,3-c]pyrazoles I [Ar = Ph, 2-furyl, 4-MeC6H4, etc.] through a four-component reaction of aromatic aldehydes, Et acetoacetate, hydrazines and malononitrile with moderate to good yields in deep eutectic solvent at room temperature The catalytic system was synthesized easily through a low-cost, non-toxic, eco-friendly and simple procedure with potential application in large-scale process.
Safety of Imidazole-4-carbaldehyde, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem