Zhang, Zhongwang; Wang, Lidong published an article in 2022, the title of the article was Using Chou’ s 5-steps rule to identify N6-methyladenine sites by ensemble learning combined with multiple feature extraction methods.Formula: C6H7N5 And the article contains the following content:
N6-methyladenine (m6A), a type of modification mostly affecting the downstream biol. functions and determining the levels of gene expression, is mediated by the methylation of adenine in nucleic acids. It is also a key factor for influencing biol. processes and has attracted attention as a target for treating diseases. Here, an ensemble predictor named as TL-Methy, was developed to identify m6A sites across the genome. TL-Methy is a 2-level machine learning method developed by combining the support vector machine model and multiple features extraction methods, including nucleic acid composition, di-nucleotide composition, tri-nucleotide composition, position-specific trinucleotide propensity, Bi-profile Bayes, binary encoding, and accumulated nucleotide frequency. For Homo sapiens, TL-Methy method reached the accuracy of 91.68% on jackknife test and of 92.23% on 10-fold cross validation test; For Mus musculus, TL-Methy method achieved the accuracy of 93.66% on jackknife test and of 97.07% on 10-fold cross validation test; For Saccharomyces cerevisiae, TL-Methy method obtained the accuracy of 81.57% on jackknife test and of 82.54% on 10-fold cross validation test; For rice genome, TL-Methy method achieved the accuracy of 91.87% on jackknife test and of 93.04% on 10-fold cross validation test. The results via these two test approaches demonstrated the robustness and practicality of our TL-Methy model. The TL-Methy model may be as a potential method for m6A site identification.Communicated by Ramaswamy H. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Formula: C6H7N5
The Article related to saccharomyces cerevisiae mus musculus methyladenine jackknife test feature extraction, 10-fold cross validation test, 2-level method, n6-methyladenine, feature extraction, jackknife test, support vector machine and other aspects.Formula: C6H7N5
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem