On August 18, 2008, Sun, Jiangtao; Yang, Minghua; Dai, Zhenya; Zhu, Chengjian; Hu, Hongwen published an article.Electric Literature of 73590-85-9 The title of the article was Synthesis of optically active 2,5-dialkylcyclohexane-1,4-diols and their application in the asymmetric oxidation of sulfides. And the article contained the following:
A simple and efficient approach to obtain optically pure 1,4-diols was established. The asym. oxidation of sulfides to sulfoxides with cumyl hydroperoxide in moderate yields and moderate to high enantioselectivities (≤84%) catalyzed by chiral Ti/1,4-diols complexes was achieved. An ee of 76% was obtained in the asym. synthesis of esomeprazole. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9
The Article related to alkylcyclohexanediol resolution chiral ligand titanium catalyzed asym oxidation, sulfide asym oxidation titanium catalyst, thioether asym oxidation titanium catalyst, sulfoxide asym synthesis, esomeprazole asym synthesis and other aspects.Electric Literature of 73590-85-9
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem