Matkarimov, Bakhyt T.; Saparbaev, Murat K. published an article in 2020, the title of the article was DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance.Electric Literature of 55662-66-3 And the article contains the following content:
A variety of endogenous and exogenous factors induce chem. and structural alterations in cellular DNA in addition to the errors occurring throughout DNA synthesis. These types of DNA damage are cytotoxic, miscoding or both and are believed to be at the origin of cancer and other age-related diseases. A human cell, aside from nuclear DNA, contains thousands of copies of mitochondrial DNA (mtDNA), a double-stranded, circular mol. of 16,569 bp. It has been proposed that mtDNA is a critical target of reactive oxygen species: byproducts of oxidative phosphorylation that are generated in the organelle during aerobic respiration. Indeed, oxidative damage to mtDNA is more extensive and persistent as compared to that to nuclear DNA. Although transversions are the hallmark of mutations induced by reactive oxygen species, paradoxically, the majority of mtDNA mutations that occur during aging and cancer are transitions. Furthermore, these mutations show a striking strand orientation bias: T→C/G→A transitions preferentially occur on the light strand, whereas C→T/A→G on the heavy strand of mtDNA. Here, we propose that the majority of mtDNA progenies, created after multiple rounds of DNA replication, are derived from the heavy strand only, owing to asym. replication of the DNA strand anchored to the inner membrane via the D-loop structure. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Electric Literature of 55662-66-3
The Article related to review mitochondrial dna mismatch repair damage mutagenesis oxidative phosphorylation, review2 ros nucleotide excision uracil, abasic sites, dna excision repair, dna glycosylases, mitochondrial dna, oxidative dna damage, uracil and other aspects.Electric Literature of 55662-66-3
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem