On March 31, 2009, Jiang, Biao; Zhao, Xiao-Long; Dong, Jia-Jia; Wang, Wan-Jun published an article.Formula: C17H19N3O2S The title of the article was Catalytic asymmetric oxidation of heteroaromatic sulfides with tert-butyl hydroperoxide catalyzed by a titanium complex with a new chiral 1,2-diphenylethane-1,2-diol ligand. And the article contained the following:
Heteroaromatic sulfoxides, especially 1H-benzimidazolyl pyridinylmethyl sulfoxides, usually used as the blockbuster gastric proton pump inhibitors (PPIs), have been prepared highly enantioselectivity by catalytic asym. oxidation of sulfides attached to nitrogen-containing heterocycles with tert-Bu hydroperoxide in the presence of a chiral titanium complex, formed in situ from Ti(iPrO)4, chiral 1,2-diphenylethane-1,2-diol and water. The chiral sulfoxides were obtained in high yield (97%) with excellent enantiomeric excess (up to 98%). The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Formula: C17H19N3O2S
The Article related to benzimidazolyl pyridinylmethyl benzyl sulfide tertbutyl hydroperoxide titanium, chiral diphenylethane diol asym oxidation sulfoxide stereoselective preparation, asym oxidation catalyst titanium chiral diphenylethane diol and other aspects.Formula: C17H19N3O2S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem