Frey, Felice; Sandakly, Jawdat; Ghannam, Mirna; Doueiry, Caren; Hugosson, Fredrik; Berlandi, Johannes; Ismail, Joy N.; Gayden, Tenzin; Hasselblatt, Martin; Jabado, Nada; Shirinian, Margret published an article in 2022, the title of the article was Drosophila tet is required for maintaining glial homeostasis in developing and adult fly brains.SDS of cas: 443-72-1 And the article contains the following content:
Ten-eleven translocation (TET) proteins are crucial epigenetic regulators highly conserved in multicellular organisms. TETs’ enzymic function in demethylating 5-Me cytosine in DNA is required for proper development and TETs are frequently mutated in cancer. Recently, Drosophila melanogaster Tet (dTet) was shown to be highly expressed in developing fly brains and discovered to play an important role in brain and muscle development as well as fly behavior. Furthermore, dTet was shown to have different substrate specificity compared with mammals. However, the exact role dTet plays in glial cells and how ectopic TET expression in glial cells contributes to tumorigenesis and glioma is still not clear. Here, we report a novel role for dTet specifically in glial cell organization and number We show that loss of dTet affects the organization of a specific glia population in the optic lobe, the “optic chiasm” glia. Addnl., we find irregularities in axon patterns in the ventral nerve cord (VNC) both, in the midline and longitudinal axons. These morphol. glia and axonal defects were accompanied by locomotor defects in developing larvae escalating to immobility in adult flies. Furthermore, glia homeostasis was disturbed in dTet-deficient brains manifesting in gain of glial cell numbers and increased proliferation. Finally, we establish a Drosophila model to understand the impact of human TET3 in glia and find that ectopic expression of hTET3 in dTet-expressing cells causes glia expansion in larval brains and affects sleep/rest behavior and the circadian clock in adult flies. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).SDS of cas: 443-72-1
The Article related to drosophila melanogaster tet glial homeostasis fly brain development, 6ma dna demethylation, drosophila ten-eleven translocation (tet), drosophila brain, brain tumor, human tet drosophila model, optic chiasm glia and other aspects.SDS of cas: 443-72-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem