Floresta, Giuseppe; Fallica, Antonino Nicolo; Patamia, Vincenzo; Sorrenti, Valeria; Greish, Khaled; Rescifina, Antonio; Pittala, Valeria published an article in 2021, the title of the article was From Far West to East: Joining the Molecular Architecture of Imidazole-like Ligands in HO-1 Complexes.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:
HO-1 overexpression has been reported in several cases/types of human malignancies. Unfortunately, poor clin. outcomes are reported in most of these cases, and the inhibition of HO-1 is considered a valuable and proven anticancer approach. To identify novel hit compounds suitable as HO-1 inhibitors, a fragment-based approach where ligand joining experiments were used was reported. The two most important parts of the classical structure of the HO-1 inhibitors were used as a starting point, and 1000 novel compounds were generated and then virtually evaluated by structure and ligand-based approaches. The joining experiments led to a novel series of indole-based compds I (R1 = Me, OMe, PhCH2O; R2 = H, OMe; R3 = Me, OMe, PhCH2). A synthetic pathway for eight selected mols. I was designed, and the compounds were synthesized. The biol. activity revealed that some mols. I reach the micromolar activity, whereas mol. I (R1 = PhCH2O; R2 = H; R3 = Me) inhibits the HO-1 with an IC50 of 1.03μM. This study suggested that joining approach was successful, and a novel hit compound I was generated. These results are ongoing for further development. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole
The Article related to imidazolyl indole carboxamide preparation sar heme oxygenase inhibitor docking, ho-1 inhibitors, fragment growing, fragment-based ligand design, heme oxygenase, imidazole, ligand joining, structure-based drug design and other aspects.Safety of N-(3-Aminopropyl)-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem