Fan, Xin; Zhang, Lingling; Huang, Junwen; Zhong, Yun; Fan, Yanting; Zhou, Tong; Lu, Min published an article in 2022, the title of the article was An integrated immune-related bioinformatics analysis in glioma: prognostic signature’s identification and multi-omics mechanisms’ exploration.Electric Literature of 443-72-1 And the article contains the following content:
As the traditional treatment for glioma, the most common central nervous system malignancy with poor prognosis, the efficacy of high-intensity surgery combined with radiotherapy and chemotherapy is not satisfactory. The development of individualized scientific treatment strategy urgently requires the guidance of signature with clin. predictive value. In this study, five prognosis-related differentially expressed immune-related genes (PR-DE-IRGs) (CCNA2, HMGB2, CASP3, APOBEC3C, and BMP2) highly associated with glioma were identified for a prognostic model through weighted gene co-expression network anal., univariate Cox and lasso regression. Kaplan-Meier survival curves, receiver operating characteristic curves and other methods have shown that the model has good performance in predicting the glioma patients’ prognosis. Further combined nomogram provided better predictive performance. The signature’s guiding value in clin. treatment has also been verified by multiple anal. results. We also constructed a comprehensive competing endogenous RNA (ceRNA) regulatory network based on the protective factor BMP2 to further explore its potential role in glioma progression. Numerous immune-related biol. functions and pathways were enriched in a high-risk population. Further multi-omics integrative anal. revealed a strong correlation between tumor immunosuppressive environment/IDH1 mutation and signature, suggesting that their cooperation plays an important role in glioma progression. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Electric Literature of 443-72-1
The Article related to prognosis idh1 apobec3c casp3 linc00689 snhg16 n6 methyladenine glioma, idh1 mutation, cerna regulatory network, glioma, mechanisms’ exploration, muti-omics immune-related bioinformatics research, prognostic model, tumor immunosuppressive environment and other aspects.Electric Literature of 443-72-1
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