On January 31, 2020, Ding, Wen; Yu, Tao; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Zhao, Shiyuan; Ma, Xiaofei; Ma, Mingxuan; Chen, Cheng published an article.Product Details of 5036-48-6 The title of the article was A metal organic framework-functionalized monolithic column for enantioseparation of six basic chiral drugs by capillary electrochromatography. And the article contained the following:
Poly(glycidyl methacrylate)-co-(ethylene dimethacrylate) [poly(GMA-co-EDMA)] monoliths were used as a support to grow a zeolitic imidazolate framework-8 (ZIF-8) via layer-by-layer self-assembly. Pepsin, acting as as chiral selector, was covalently linked to the surface of the amino-modified ZIF-8 through the Schiff base method. The material was characterized by SEM, thermogravimetric anal., X-ray diffraction, Fourier transform IR spectroscopy and elemental anal. The pepsin-ZIF-8-poly(GMA-co-EDMA) column was utilized to the enantioseparation of the racemic forms of hydroxychloroquine (HCQ), chloroquine (CHQ), hydroxyzine (HXY), nefopam (NEF), clenbuterol (CLE) and amlodipine (AML). In comparison with a pepsin-poly(GMA-co-EDMA) monolithic column (without self-assembled ZIF-8 nanoparticles), the resolution is strongly enhanced (HCQ: 0.34 → 2.50; CHQ: 0.45 → 1.97; HXY: 0.39 → 1.43; NEF: 0.27 → 0.81; CLE: 0 → 0.81; AML: 0.16 → 0.72). Effects of self-assembly layers of ZIF-8, pepsin concentration, buffer pH values and applied voltage were investigated with hydroxychloroquine as the model analyte. The reproducibility of run-to-run, day-to-day and column-to-column were explored, and found to be satisfactory. [Figure not available: see fulltext.]. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6
The Article related to metal organic framework monolithic column enantioseparation capillary electrochromatog, basic drugs, capillary electrochromatography, enantioseparation, glycidyl methacrylate, metal-organic framework, monolithic column, nanoparticles, pepsin, self assembly, zif-8 and other aspects.Product Details of 5036-48-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem