On January 9, 2020, Bartlett, Mark J.; Corkey, Britton Kenneth; Cosman, Jennifer Leigh; Elzein, Elfatih; Li, Xiaofen published a patent.Electric Literature of 40644-16-4 The title of the patent was Preparation of indoles, azaindoles and related bicyclic nitrogen heterocycles useful in treatment of diseases. And the patent contained the following:
The invention relates to preparation of indoles, azaindoles and related bicyclic nitrogen heterocycles of formula (I), or a pharmaceutically acceptable salt thereof, as enzyme indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Compounds I wherein Y1 is O or N; the dotted line is a single bond that is present or absent; X1, X2 and X4 each independently is N or CH; X3 is N or CRa; Ra is H, halo, C1-4 alkyl; X5 is N, C or CRb; X6 is N or CRc; X7 is N or CRd; X8 is N or CRe; Rb-Re and R1 each independently is H, halo, or CN; R2 is C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy; etc., are claimed. The example compound II was prepared via two-step synthesis using 4-bromo-3,3-dimethylindolin-2-one as starting material (procedure given). Compounds I were evaluated for IDO1-inhibitory activity (data given). Compounds I can be useful in mono- amd combination therapy of cancer and viral infections (e.g. HIV and HBV). The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Electric Literature of 40644-16-4
The Article related to indole preparation ido1 inhibitor antitumor hbv hiv antiviral therapy, azaindole preparation ido1 inhibitor cancer viral infection combination therapy, bicyclic nitrogen heterocycle preparation ido1 inhibitor immunotherapy anticancer antiviral and other aspects.Electric Literature of 40644-16-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem