Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 60-56-0, formula is C4H6N2S, Name is 1-Methyl-1H-imidazole-2(3H)-thione. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Related Products of 60-56-0.
Li, Zijian research published 《 Prioritizing agricultural pesticides to protect human health: A multi-level strategy combining life cycle impact and risk assessments》, the research content is summarized as follows. In this study, a multi-level strategy to prioritize pesticides for use in agriculture is proposed in support of protecting human health. The strategy includes four levels (production application, distribution, and bioaccumulation) of screening approaches, for which the life cycle impact assessment (LCIA) and human health risk assessment (HHRA) models were applied to generate priority lists at each level. The LCIA model was used at the production level (i.e., chem. design; before pesticides being registered and entering the market), providing the inventory management based on environmental persistence and toxicity potential of pesticides, whereas the HHRA models were used at the other three levels, assessing human health risks based on pesticide emission to cropland. Priority scores (PS) of 319 pesticides were simulated with high scores indicating high priority for use in agriculture (relatively high human safety). The simulated results via the LCIA at the production level had strong pos. correlations with those via the HHRA at the other three levels, indicating that the LCIA tool was capable of an initial screening of pesticides for use in agriculture. The simulated PS values of 319 pesticides indicated that some pesticides (e.g., chlorpyrifos and fipronil) with low PS values (e.g., #x003C;8) that are currently used in some countries should be further evaluated. For other pesticides with high simulated PS values (e.g., #x003E;15) for use in agriculture, their ecotoxicity impacts and ecol. risks should be considered in protecting human health.
Related Products of 60-56-0, Methimazole is an antithyroid compound found to have antioxidant properties. Methimazole inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway in FRTL-5 thyroid cells, which may account for its immunodolulatory effects. Additionally, methimazole is an inhibitor of thyroperoxidase.
Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid.
Methimazole is an inhibitor of thyroid hormone synthesis. It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.3 It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat. Methimazole has been used to induce hypothyroidism in mice. Formulations containing methimazole have been used in the treatment of hyperthyroidism.
Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.
Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.
Methimazole, also known as tapazole or danantizol, belongs to the class of organic compounds known as imidazolethiones. These are aromatic compounds containing an imidazole ring which bears a thioketone group. Methimazole is a drug which is used for the treatment of hyperthyroidism, goiter, graves disease and psoriasis. Methimazole is soluble (in water) and a very weakly acidic compound (based on its pKa). Methimazole has been detected in multiple biofluids, such as urine and blood. Methimazole can be converted into methimazole S-oxide., 60-56-0.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem