Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. 3034-50-2, formula is C4H4N2O, Name is Imidazole-4-carbaldehyde. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen. Recommanded Product: Imidazole-4-carbaldehyde.
Li, Min-Xin;Pu, Xiao-Jia;Zhang, Xia;Zheng, Xi;Gao, Hui;Xiao, Wei-Lie;Wan, Chun-Ping;Mao, Ze-Wei research published 《 Synthesis and Biological Evaluation of Heterocyclic Substituted Bis(indolyl)methanes》, the research content is summarized as follows. A series of heterocyclic substituted bis(indolyl)methanes I (het = 2-furyl, 3-thienyl, 3-indolyl, etc.) have been prepared by boron trifluoride etherate catalyzed condensation reaction of indole and heterocyclic aldehydes with high yields. Preliminary in vitro anti-inflammatory in lipopolysaccharide (LPS)-stimulated RAW-264.7 macrophages and cytotoxic activity against human tumor cell lines (A549, Hela and SGC7901) by MTT assay were tested. The result indicated that heterocyclic substituted bis(indolyl)methanes showed good antiinflammatory and selective cytotoxic activity. Especially, compounds I (het = 3-indolyl), I (het = 1H-pyrrolo[2,3-b]pyridine-3-yl) and I (het = quinolin-3-yl) displayed similar inhibitory effect on the generation of NO to pos. control dexamethasone, and compound I (het = quinolin-3-yl) displayed similar selective cytotoxic activity to 5-FU. Heterocyclic substituted bis(indolyl)methanes may be used as potential anti-inflammatory and anticancer leads.
Recommanded Product: Imidazole-4-carbaldehyde, 1H-Imidazole-4-carbaldehyde, also known as 1H-Imidazole-4-carbaldehyde, is a useful research compound. Its molecular formula is C4H4N2O and its molecular weight is 96.09 g/mol. The purity is usually 95%.
The starting material for a practical synthesis of a potent C17,20-lyase inhibitor. The lyase is a key enzyme in androgen biosynthesis as well as a target for treatment of androgen-dependent prostate cancer. Used to synthesize potent antimalarial drug.
1H-Imidazole-4-carbaldehyde is a chemical compound that has been shown to bind to the glucocorticoid receptor. It was synthesized by reacting 1,2-diaminobenzene with formaldehyde and then hydrolyzing the intermediate imidazolium salt, which is stable in acidic solutions. The complex can be prepared by mixing two solutions of imidazole and trifluoroacetic acid. The ligand has a redox potential of -0.1 V (vs NHE). This means it can be oxidized to the carbonyl group or reduced back to the imidazole ring. The compound is stable in neutral solution and forms stable complexes with metal ions such as Cu+, Fe3+, and Zn2+. It also coordinates well with oxygen atoms, nitrogen atoms, and water molecules. 1H-Imidazole-4-carbaldehyde has been shown to bind to glucocortic, 3034-50-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem