Computed Properties of C8H5N3On October 10, 2016 ,《Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles》 was published in ACS Combinatorial Science. The article was written by Tolmachev, Andrey; Bogolubsky, Andrey V.; Pipko, Sergey E.; Grishchenko, Alexander V.; Ushakov, Dmytro V.; Zhemera, Anton V.; Viniychuk, Oleksandr O.; Konovets, Anzhelika I.; Zaporozhets, Olga A.; Mykhailiuk, Pavel K.; Moroz, Yurii S.. The article contains the following contents:
One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chem. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in moderate yields. Practical application of the approach was demonstrated in the synthesis of bioactive compound pifexole, I, and agonists of free fatty acid receptor 1. A library of 4,948,100 synthesizable drug-like 3,5-disubstituted 1,2,4-oxadiazoles was enumerated based on the method and available validated reagents. The results came from multiple reactions, including the reaction of Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9Computed Properties of C8H5N3)
Imidazo[1,2-a]pyridine-8-carbonitrile(cas: 136117-70-9) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Computed Properties of C8H5N3 However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem