《Cytotoxic effects of gold(I) complexes against colon, cervical and osteo carcinoma cell lines: a mechanistic approach》 was published in New Journal of Chemistry in 2019. These research results belong to Sulaiman, Adam A. A.; Kalia, Namarta; Bhatia, Gaurav; Kaur, Manpreet; Fettouhi, Mohammed; Altaf, Muhammad; Baig, Nadeem; Kawde, Abdel-Nasser; Isab, Anvarhusein A.. SDS of cas: 852445-84-2 The article mentions the following:
Water-soluble gold(I) complexes, [Au(Ipr)(L)]PF6 where L = thiourea (Tu) 1 and N,N’-dimethylthiourea (Me2Tu) 2, were synthesized from the parent 1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidenechloridogold(I) [(Ipr)AuCl] (0). The complexes (0-2) were fully characterized using elemental anal. (EA), FT-IR, 1H and 13C NMR spectroscopy. Single crystal X-ray diffraction anal. shows that both complexes have a near linear geometry. We investigated the in vitro cytotoxic activity of the complexes and cisplatin using an MTT assay against human osteosarcoma (MG-63), colon adenocarcinoma (HCT15), and cervical cancer (HeLa) cell lines. The IC50 values showed that the complexes 1 and 2 exhibit cytotoxicity higher than that of cisplatin against all cancer cell lines. The complex 2 exhibited cytotoxicity less than that of cisplatin against HeLa. The interaction of the complexes with amino acids was tested electrochem. in a phosphate buffer aqueous solution using cyclic voltammetry. Complex 1 interacted more with L-tryptophan than complex 2. The interaction of both complexes with L-tryptophan resulted in the reduction in peak height and peak current of L-tryptophan. Studying the expression levels of caspase-3 and caspase-9 genes provided insight into the cell death mechanism. The treatment of the HCT-15 and HeLa cells with complex 1 resulted in the induction of apoptosis and a significant up-regulation in the expression of both caspase-3 and 9. No significant deviation was noted in the expression of the MG-63 cells treated with complex 1. In addition to this study using Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I), there are many other studies that have used Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2SDS of cas: 852445-84-2) was used in this study.
Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. SDS of cas: 852445-84-2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem