In 2008,Primas, Nicolas; Bouillon, Alexandre; Lancelot, Jean-Charles; Sopkova-de Oliveira Santos, Jana; Lohier, Jean-Francois; Rault, Sylvain published 《A new methodology to prepare 2-halogenoimidazoles via a N-THP protection》.Letters in Organic Chemistry published the findings.Recommanded Product: 16681-56-4 The information in the text is summarized as follows:
A straightforward access to 2-halogenoimidazoles via a N-THP protection was described in this paper. The N-THP protecting group is easily introduced by reaction of 2-chloro-THP with imidazole. Lithiation followed by reaction with an appropriate electrophile affords 2-halogeno N-THP derivatives The THP protecting group is then cleaved to get the title compounds in good to high yields. The structures of the compounds were confirmed by x-ray diffraction anal. (data not given). In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-1H-imidazole(cas: 16681-56-4Recommanded Product: 16681-56-4)
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Recommanded Product: 16681-56-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem