Prasoona, Gumpula; Kishore, Baireddy; Brahmeshwari, Gavaji published their research in Letters in Organic Chemistry in 2021. The article was titled 《Synthesis and Antimicrobial Evaluation of Benzimidazolyl Pyrimido[4,5-b]Quinolinones》.HPLC of Formula: 934-32-7 The article contains the following contents:
The reaction of 2-amino benzimidazoles with Et cyanoacetate afforded N-(1H-benzo[d]imidazol-2-yl)-2-cyanoacetamides I (R = H, Cl, NO2, Me, etc.). Compounds I on Knoevenagel condensation with o-nitro benzaldehydes produced (E)-N-(1H-benzo[d]imidazol-2-yl)-2-cyano-3-(2-nitrophenol) acylamides II (R1 = H, Cl, OMe). Compounds II were converted to 2-amino-N-(1H-benzo[d]imidazol-2-yl) quinoline-3-carboxamides III on treatment with stannous chloride by reductive cyclization. The target compounds viz., 3-(1H-benzo[d]imidazol-2-yl)-2-methylpyrimido[4,5-b]quinolin-4(3H)-ones IV were obtained by N-acetylation followed by cyclodehydration of compounds III in situ by treatment with acetic anhydride. 3-(1H-Benzo[d]imidazol-2-yl)-2-methylpyrimido[4,5-b]quinolin-4(3H)-ones IV have been synthesized from com. available materials in excellent yields. The title compounds IV are evaluated for in vitro antimicrobial activity. Compounds IV (R = Me; R1 = H), IV (R = OMe; R1 = H) and IV (R = H; R1 = OMe) have shown more antimicrobial activity than that of standard drugs. The structures of all the newly synthesized compounds I, II, III & IV are confirmed on the basis of spectral data. Antimicrobial studies of compounds IV have revealed that compounds IV (R = Me; R1 = H) and IV (R = OMe; R1 = H) have more efficient activity when compared to the standard drugs. In the experimental materials used by the author, we found 1H-Benzo[d]imidazol-2-amine(cas: 934-32-7HPLC of Formula: 934-32-7)
1H-Benzo[d]imidazol-2-amine(cas: 934-32-7) can be used in the hydrolysis of a choline carbonate. It was also used in the synthesis of imidazo[1,2-a]benzimidazoles.HPLC of Formula: 934-32-7
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem