In 2020,Advances in Inorganic Chemistry included an article by Ott, Ingo. Product Details of 258278-25-0. The article was titled 《Metal N-heterocyclic carbene complexes in medicinal chemistry》. The information in the text is summarized as follows:
A review. Based on their strong s-donor properties N-heterocyclic carbene (NHC) ligands can form stable complexes with many transition metals. Numerous applications of metal NHC complexes have been developed in the field of chem. catalysis. The option to generate very stable complexes as well as the convenient access to a high number of structurally diverse NHC ligands have made them also attractive target compounds in inorganic medicinal chem. A fast increasing number of reports demonstrates that metal NHC complexes provide an excellent scaffold for metallodrug design and many examples have been studied pharmacol. in great detail. This chapter focuses on metal NHC complexes containing the selected metals ruthenium, rhodium, silver, iridium and gold. In the experiment, the researchers used many compounds, for example, 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0Product Details of 258278-25-0)
1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride(cas: 258278-25-0) has been employed in an efficient, one-pot synthesis of N-heterocyclic carbene-allylpalladium complexes.Product Details of 258278-25-0In addition, it can efficiently catalyze the Suzuki-Miyaura coupling of aryl chlorides with aryl boronic acids.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem