Montel, Sonia; Midrier, Camille; Volle, Jean-Noel; Braun, Ralf; Haaf, Klaus; Willms, Lothar; Pirat, Jean-Luc; Virieux, David published the artcile< Functionalized Phosphanyl-Phosphonic Acids as Unusual Complexing Units as Analogues of Fosmidomycin>, COA of Formula: C4H5BrN2, the main research area is phosphinic phosphonic acid preparation fosmidomycin analog.
Fosmidomycin and FR-90098 are potent inhibitors of 1-deoxy-L-xylulose-5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate (MEP) pathway responsible for the biosynthesis of isoprenoids. This paper describes the synthesis of four types of targets bearing a phosphanyl-phosphonic acid motif as the common core for the inhibition of DXR. In these structures, the hydroxamic acid was replaced by various chelators based on a phosphinic acid linked to different functional groups capable of forming five- or six-membered chelating rings.
European Journal of Organic Chemistry published new progress about Phosphinates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, COA of Formula: C4H5BrN2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem