Application In Synthesis of Di(1H-imidazol-1-yl)methanoneIn 2022 ,《Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Manetti, Fabrizio; Maresca, Luisa; Crivaro, Enrica; Pepe, Sara; Cini, Elena; Singh, Snigdha; Governa, Paolo; Maramai, Samuele; Giannini, Giuseppe; Stecca, Barbara; Petricci, Elena. The article conveys some information:
A virtual screening approach based on a five-feature pharmacophoric model for neg. modulators of GLI1 was applied to databases of com. available compounds The resulting quinoline derivatives showed significant ability to reduce the GLI1 protein level and were characterized by submicromolar antiproliferative activity toward human melanoma A375 and medulloblastoma DAOY cell lines. Decoration of the quinoline ring and chem. rigidification to an oxazino-quinoline scaffold allowed us to deduce SAR considerations for future ligand optimization.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Application In Synthesis of Di(1H-imidazol-1-yl)methanone) was used in this study.
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Application In Synthesis of Di(1H-imidazol-1-yl)methanone
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem