Name: Di(1H-imidazol-1-yl)methanoneIn 2019 ,《Gold nano-urchin integrated label-free amperometric aptasensing human blood clotting factor IX: A prognosticative approach for “”Royal disease””》 was published in Biosensors & Bioelectronics. The article was written by Letchumanan, Iswary; Gopinath, Subash C. B.; Arshad, M. K. Md; Anbu, Periasamy; Lakshmipriya, Thangavel. The article contains the following contents:
This article is clearly presenting the development of a biosensor for human factor IX (FIX) to diagnose the blood clotting deficiency, a so-called ‘Royal disease’ using an interdigitated electrode (IDE) with the zinc oxide surface modification. Gold nano-urchins (GNUs) with 60 nm in diameter was integrated into a streptavidin-biotinylated aptamer strategy to enhance the active surface area. Two different comparative studies have been done to validate the system to be practiced in the current work holds with a higher capability for the high-performance sense. Whereby, the presence and absence of GNUs in the aptasensing system for FIX interaction were investigated using the amperometric measurement, using a linear sweep voltage of 0-2 V at 0.01 V step voltage. The detection limit was 6 pM based on 3s calculation when GNUs integrated aptamer assay was utilized for FIX detection, which shows 8 folds sensitivity enhancement comparing the condition in the absence of GNU and 50 folds higher than sensitive radio-isotope and surface plasmon resonance assays. Albeit, the surface and mol. characterizations were well demonstrated by SEM, at. force microscopy, 3D nano-profilometry and further supports were rendered by UV-Vis spectroscopy and Enzyme-linked apta-sorbent assay (ELASA). Furthermore, the spiking experiment was done by FIX-spikes in human blood serum in order to demonstrate the stability with a higher non-fouling.Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Name: Di(1H-imidazol-1-yl)methanone) was used in this study.
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Name: Di(1H-imidazol-1-yl)methanone
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem