Quality Control of 1H-Imidazol-2-amineIn 2017 ,《Synthesis and characterization of S(-)1-phenyl-1,2,3,4-tetrahydro isoquinoline acetamide analogues》 was published in Asian Journal of Chemistry. The article was written by Krishna Rao, N.; Surendra Babu, M.; Basaveswara Rao, M. V.; Keshavi, R.; Sundara Rao, N.; Eswara Prasad, N. H.; Murthy, Y. L. N.. The article contains the following contents:
S(-)1-Phenyl-1,2,3,4-tetrahydroisoquinoline acetamide analogs are prepared by sequence of reactions which involve a metal hydride reduction of 3,4-dihydroisoquinoline followed by separation of S-form with mandelic acid (chiral reagent) by resolution The product S(-)1-phenyl-1,2,3,4-tetrahydroisoquinoline is treated with chloroacetyl chloride to obtain tetrahydroisoquinoline acetyl chloride which is further employed to synthesize acetamide derivatives of tetrahydroisoquinoline I [R = Ph, 4-hydroxyphenyl, pyrimidin-2-yl, etc.] using various substituted aryl amines RNH2. The products were characterized by advanced spectroscopic techniques.1H-Imidazol-2-amine(cas: 7720-39-0Quality Control of 1H-Imidazol-2-amine) was used in this study.
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 1H-Imidazol-2-amine
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem