Ibrahim, Mansur; Malik, Imran; Mansour, Waseem; Sharif, Muhammad; Fettouhi, Mohammed; El Ali, Bassam published the artcile< Novel (N-heterocyclic carbene)Pd(pyridine)Br2 complexes for carbonylative Sonogashira coupling reactions: Catalytic efficiency and scope for arylalkynes, alkylalkynes and dialkynes>, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole, the main research area is palladium heterocyclic carbene pyridine catalyst preparation crystal structure mol; alkynyl ketone preparation; aryl iodide terminal alkyne carbonylative Sonogashira coupling palladium catalyst.
New N,N’-substituted imidazolium salts and their corresponding dibromidopyridine-palladium(II) complexes I [R = 2-methyl-Pr, Bn] were successfully synthesized and characterized. Protocol started with Suzuki-Miyaura cross-coupling reaction of 5-bromo-1-methyl-1H-imidazole with phenylboronic acid followed by direct alkylation with either iso-Bu bromide/benzyl bromide to yield N,N’-substituted imidazolium bromides. Reactions of palladium bromide with this newly synthesized N,N’-substituted imidazolium bromides in pyridine afforded the corresponding new N-heterocyclic carbene pyridine palladium(II) complexes I in high yields. Their single-crystal X-ray structures showed a distorted square planar geometry with carbene and pyridine ligands in trans position. Both complexes exhibited a high catalytic activity in carbonylative Sonogashira coupling reactions of aryl iodides/aryl diiodides with various alkynes and hence gave alkynyl ketones R1C(O)C≡CR2 [R1 = Ph, 4-NCC6H4, 4-MeC6H4, etc.; R2 = Pr, Ph, 4-t-BuC6H4, etc.].
Applied Organometallic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-21-0 belongs to class imidazoles-derivatives, and the molecular formula is C4H5BrN2, Recommanded Product: 5-Bromo-1-methyl-1H-imidazole.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem