In 2018,Himabindu, Vittam; Parvathaneni, Sai Prathima; Rao, Vaidya Jayathirtha published 《PhI(OAc)2/NaX-mediated halogenation providing access to valuable synthons 3-haloindole derivatives》.New Journal of Chemistry published the findings.Reference of 2-Bromo-1H-imidazole The information in the text is summarized as follows:
A mild phenyliodine diacetate mediated method for selective chlorination, bromination, and iodination of indole C-H bonds using sodium halides NaX (X = Cl, Br, I) as a source for analogus halogenations has been described. The combination of sodium halide and phenyliodine diacetate provides an invincible system for halogenation of indoles I (R = H, F, Cl, Br, I, NO2, CH3, OCH3; R1 = H, CH3, C6H5; R2 = H, CH3, C6H5, C6H5CH2; X = H). This protocol was compatible with a wide array of indole substrates and provides straight forward access to potential halogenated arenes I (X = Cl, Br, I). In the experiment, the researchers used many compounds, for example, 2-Bromo-1H-imidazole(cas: 16681-56-4Reference of 2-Bromo-1H-imidazole)
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Reference of 2-Bromo-1H-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem