Bandela, Anil Kumar; Wagner, Nathaniel; Sadihov, Hava; Morales-Reina, Sara; Chotera-Ouda, Agata; Basu, Kingshuk; Cohen-Luria, Rivka; de la Escosura, Andres; Ashkenasy, Gonen published the artcile< Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks>, Formula: C5H5N5, the main research area is functional synergy nucleopeptide network; chemical evolution; molecular networks; nucleic-acid–peptide conjugates; self-replication.
Many fundamental cellular and viral functions, including replication and translation, involve complex ensembles hosting synergistic activity between nucleic acids and proteins/peptides. There is ample evidence indicating that the chem. precursors of both nucleic acids and peptides could be efficiently formed in the prebiotic environment. Yet, studies on nonenzymic replication, a central mechanism driving early chem. evolution, have focused largely on the activity of each class of these mols. sep. We show here that short nucleopeptide chimeras can replicate through autocatalytic and cross-catalytic processes, governed synergistically by the hybridization of the nucleobase motifs and the assembly propensity of the peptide segments. Unequal assembly-dependent replication induces clear selectivity toward the formation of a certain species within small networks of complementary nucleopeptides. The selectivity pattern may be influenced and indeed maximized to the point of almost extinction of the weakest replicator when the system is studied far from equilibrium and manipulated through changes in the phys. (flow) and chem. (template and inhibition) conditions. We postulate that similar processes may have led to the emergence of the first functional nucleic-acid-peptide assemblies prior to the origin of life. Furthermore, spontaneous formation of related replicating complexes could potentially mark the initiation point for information transfer and rapid progression in complexity within primitive environments, which would have facilitated the development of a variety of functions found in extant biol. assemblies.
Proceedings of the National Academy of Sciences of the United States of America published new progress about Autocatalysis. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Formula: C5H5N5.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem