Ogino, Yoshio; Ohtake, Norikazu; Nagae, Yoshikazu; Matsuda, Kenji; Moriya, Minoru; Suga, Takuya; Ishikawa, Makoto; Kanesaka, Maki; Mitobe, Yuko; Ito, Junko; Kanno, Tetsuya; Ishihara, Akane; Iwaasa, Hisashi; Ohe, Tomoyuki; Kanatani, Akio; Fukami, Takehiro published the artcile< Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives>, HPLC of Formula: 401567-00-8, the main research area is isobenzofuran piperidinyl benzimidazole preparation neuropeptide Y Y5 receptor antagonist; NPY Y Y5 receptor antagonist sar isobenzofuran piperidinyl benzimidazole.
Design, syntheses, and structure-activity relationships of a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole NPY Y5 receptor antagonists are described. The benzimidazole structures were newly designed based on the urea linkage of our prototype Y5 receptor antagonists. By optimizing substituents on the benzimidazole core part of the lead compound I (R = H), a potent, orally available, and brain-penetrable Y5 selective antagonist I (R = CF3) was developed.
Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 401567-00-8 belongs to class imidazoles-derivatives, and the molecular formula is C8H4ClN3, HPLC of Formula: 401567-00-8.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem