Li, Qian; Liu, Shenbin; Zhu, Xiaocang; Mi, Wenli; Maoying, Qiliang; Wang, Jun; Yu, Jin; Wang, Yanqing published the artcile< Hippocampal PKR/NLRP1 Inflammasome Pathway Is Required for the Depression-Like Behaviors in Rats with Neuropathic Pain>, Electric Literature of 452-06-2, the main research area is depression neuropathic pain IL1beta PKR NLRP1 inflammasome animal behavior; PKR; anxiety; depression; hippocampus; inflammasome; pain.
The chronic neuropathic pain-associated psychiatric disorders have seriously disturbed the quality of patients’ life, such as depression and anxiety. Neuroinflammation in the hippocampus plays an important role in the neuropathic pain-associated depressive and anxiety disorders, but the underlying mechanism has not been thoroughly elucidated to date. The (NLRP)-1 inflammasome, which controls the production of pro-inflammatory cytokines, was broadly involved in the neuroinflammation-related diseases. In the present study, we show that the NLRP1 inflammasome is significantly activated in the hippocampus of rats subjected to the (CCI)-induced neuropathic pain. Inhibiting the product of NLRP1 inflammasome not only attenuated the depression-like behaviors but also suppressed the production of mature IL-1β in the hippocampus of CCI rats. The double-stranded RNA-dependent protein kinase has been recently shown to be a pivotal regulator for the activation of inflammasome. Functional inhibition of PKR suppressed the NLRP1 inflammasome activation and effectively attenuated the CCI-induced depression-like behaviors. These results indicate that the hippocampal PKR/NLRP1 inflammasome pathway play an important role in the development of the depressive behaviors after chronic neuropathic pain. Thus, interrupting this pathway might provide a novel therapeutic strategy for neuropathic pain-associated depressive disorders.
Neuroscience (Amsterdam, Netherlands) published new progress about Allodynia. 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, Electric Literature of 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem