Hu, Ming-Hao; Lin, Jia-Hong; Huang, Qiong published the artcile< Discovery of a fluorescent, long chain-bridged bispurine that selectively targets the c-MYC G-quadruplex>, SDS of cas: 452-06-2, the main research area is c MYC VEGF HRAS BCL2; Bispurine; Fluorescent; G-quadruplex; Selective; c-MYC.
G-quadruplexes (G4s) are special nucleic acid structures which are involved in the regulation of some key biol. events like transcription and translation, which are now treated as promising therapeutic targets for cancers. Stabilizing the promoter G4 by small-mol. ligands can suppress the c-MYC oncogene transcription, thus inhibiting cancer cell proliferation. So far, targeting the very structure, a number of ligands have been reported. However, most of them showed unsatisfactory specificity to the c-MYC G4 over other G4s, resulting in uncertain side effects. In this contribution, we discovered a new class of bispurines bridged with flexible hydrocarbon chains, which presented somewhat selectivity to the c-MYC G4 possibly by adaptive binding, which then showed clear inhibition on the c-MYC expression rather than other G4-driven oncogenes. Moreover, these novel mols. had the potential to fluorescently label G4s. We believed that this study may shed light on the discovery of new functional small mols. targeting a specific G4 structure.
Bioorganic Chemistry published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (HRAS). 452-06-2 belongs to class imidazoles-derivatives, and the molecular formula is C5H5N5, SDS of cas: 452-06-2.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem