《A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window》 was written by Zhang, Zhiyue; Li, Hui; Kasmi, Sabah; Van Herck, Simon; Deswarte, Kim; Lambrecht, Bart N.; Hoogenboom, Richard; Nuhn, Lutz; De Geest, Bruno G.. Reference of Di(1H-imidazol-1-yl)methanoneThis research focused onUCST polymer hydroxypropylmethacrylamide stimulus responsive biomaterial sustained release; UCST; degradable polymers; gels; protein delivery; responsive polymers. The article conveys some information:
Interactive materials that can respond to a trigger by changing their morphol., but that can also gradually degrade into a fully soluble state, are attractive building blocks for the next generation of biomaterials. Herein, we design such transiently responsive polymers that exhibit UCST behavior while gradually losing this property in response to a hydrolysis reaction in the polymer side chains. The polymers operate within a physiol. relevant window in terms of temperature, pH, and ionic strength. Whereas such behavior has been reported earlier for LCST systems, it is at present unexplored for UCST polymers. Furthermore, we demonstrate that, in contrast to LCST polymers, in aqueous medium the UCST polymer forms a coacervate phase below the UCST, which can entrap a hydrophilic model protein, as well as a hydrophobic dye. Because of their non-toxicity, we also provide in vivo proof of concept of the use of this coacervate as a protein depot, in view of sustained-release applications. The experimental process involved the reaction of Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Reference of Di(1H-imidazol-1-yl)methanone)
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a coupling agent in the synthesis of dipolar polyamides for nonlinear optical applications and polypeptides. It also used to make β-keto sulfones and sulfoxides, lead sequestering agents, and β-enamino acid derivatives.Reference of Di(1H-imidazol-1-yl)methanone
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem