In 2022,Yuan, Shuai; Han, Yaguang; Xiang, Dong; Wang, Bo; Chen, Yi; Hao, Yangquan published an article in Nanomedicine (New York, NY, United States). The title of the article was 《An injectable hydroxypropyl-β-cyclodextrin cross-linked gelatin-based hydrogel loaded bone mesenchymal stem cell for osteogenic and in vivo bone regeneration of femoral head necrosis》.Application of 530-62-1 The author mentioned the following in the article:
An injectable hydroxypropyl-β-cyclodextrin (HPβCD) crosslinking of gelatin (Gel) based hydrogel was embedded with BMSC in vivo bone regeneration of femoral head necrosis. This HPβCD-Gel hydrogel possesses quick gelation within 6 min; a high-water uptake resulted in faster biodegradation, high swelling, and a 3D porous network that strengthened its mech., surface, and morphol. properties. The results indicated that BMSC showed high cell viability (>90%) during measurement; HPβCD-Gel hydrogels induced BMSC differentiation into osteocytes within 14 days more efficiently than the osteogenic medium. The HPβCD-Gel/BMSC hydrogels that were injected into the necrosis site of the femoral head in the vessels were measured for 2 wk. In addition, the vessel d. and mean vessel diameters increased in the next 2-8 wk followed by increased new bone formation, according to the in vivo anal. Overall, our findings show that this method is a promising strategy for improving femoral head necrosis bone regeneration. After reading the article, we found that the author used Di(1H-imidazol-1-yl)methanone(cas: 530-62-1Application of 530-62-1)
Di(1H-imidazol-1-yl)methanone(cas: 530-62-1) is a peptide coupling reagent,it is used in the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly.Application of 530-62-1
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem