《Design, synthesis and nematicidal activitives of trifluorobutene amide derivatives against Meloidogyne incognita》 was written by Yang, Haiping; Zhang, Ruifeng; Li, Zhong; Maienfisch, Peter; Xu, Xiaoyong. SDS of cas: 7720-39-0This research focused ontrifluorobutene amide derivative synthesis treatment nematode nematicide; Amide; In vitro; In vivo; Nematicidal activity; Trifluorobutene. The article conveys some information:
Plant parasitic nematodes have always been a pressing problem in the field of plant protection. Well-established chem. nematicides, especially organophosphorus and carbamates are the most used products for nematode control worldwide. Due to long-term overuse, they have developed serious resistance and new innovative solutions are urgently required. In this study, thirty-one novel trifluorobutene amide derivatives were designed and synthesized, and their nematicidal activities were determined Three different synthetic methods have been developed for the final amidation reaction enabling the successfully syntheses of the target compounds independently from the nucleophilicities of the substrate amino group. Most target compounds showed good nematicidal activity in our in vitro test. Among all the compounds, compounds I and II exhibited excellent nematicidal activity against Meloidogyne incognita, their LC50 values are 2.02 mg L-1 and 0.76 mg L-1, resp. In particular, compound II has found to be almost as active as the com. nematicide fluensulfone. Furthermore, most compounds gave full control (100% inhibition) of M. incognita at 40 mg L-1 in the in vivo tests in sandy soil, the best compounds were further investigated for in vivo activity in matrix soil. Among the compound tested, compound I showed excellent in vivo nematicidal activity. At a concentration of 5 mg L-1 still 56% inhibition was observed The results of our study indicate that compound I possesses excellent in vitro and in vivo nematicidal activity, and can be considered as promising lead mol. for further modification. In the part of experimental materials, we found many familiar compounds, such as 1H-Imidazol-2-amine(cas: 7720-39-0SDS of cas: 7720-39-0)
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 7720-39-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem