《Simple Synthetic Routes to N-Heterocyclic Carbene Gold(I)-Aryl Complexes: Expanded Scope and Reactivity》 was written by Tzouras, Nikolaos V.; Saab, Marina; Janssens, Wim; Cauwenbergh, Thibault; Van Hecke, Kristof; Nahra, Fady; Nolan, Steven P.. Category: imidazoles-derivatives And the article was included in Chemistry – A European Journal on April 28 ,2020. The article conveys some information:
Transmetalation of arylboronic acids with gold(I) NHC chlorides [LAuCl] afforded arylgold complexes [LAuAr] (Ar = substitutted Ph, 1-naphthyl, 2-furyl; L = 1,3-bis(diisopropylphenyl)-2-imidazolylidene, 4,5-dichloro-1,3-bis(diisopropylphenyl)-2-imidazolylidene, 1,3-di-1-adamantyl-2-imidazolylidene, 1,3-di-tert-butyl-2-imidazolylidene, PPh3). Reactivity of arylgold complexes [LAuAr] towards OH-, NH- and CH-acids (HX) was explored, giving access to complexes [LAuX]. The discovery of sustainable and scalable synthetic protocols leading to gold-aryl compounds bearing N-heterocyclic carbene (NHC) ligands sparked an investigation of their reactivity and potential utility as organometallic synthons. The use of a mild base and green solvents provide access to these compounds, starting from widely available boronic acids and various [Au(NHC)Cl] complexes, with reactions taking place under air, at room temperature and leading to high yields with unprecedented ease. One compound, (N,N’-bis[2,6-(diisopropyl)phenyl]-2-imidazolylidene)(4-methoxyphenyl)gold, ([Au(IPr)(4-MeOC6H4)]), was synthesized on a multigram scale and used to gauge the reactivity of this class of compounds towards C-H/N-H bonds and with various acids, revealing simple pathways to gold-based species that possess attractive properties as materials, reagents and/or catalysts. In the experiment, the researchers used many compounds, for example, Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Category: imidazoles-derivatives)
Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Category: imidazoles-derivatives Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem