The author of 《Cationic heteroaromatic carbamates as acetylcholinesterase inhibitors. Synthesis and inhibitory activity of 5-, 6-, 7- and 8-carbamoyloxy derivatives of 2-substituted imidazo[1,2-a]pyridinium salts》 were Sundberg, Richard J.; Van Nguyen, Phuoc; Jiang, Songchun. And the article was published in Medicinal Chemistry Research in 1997. Formula: C8H8N2O The author mentioned the following in the article:
A series of 1-Me 5-, 6-, 7-, and 8-N,N-dimethylcarbamoyloxy derivatives of imidazo[1,2-a]pyridinium salts with varying 2-substituents (H, Me, Me2CH, Ph) was prepared The inhibitory activity against acetylcholinesterase (AChE) was determined The 5- and 8-substituted compounds are active as AChE inhibitors in the submicromolar range and show significant acute toxicity. The AChE inhibitory activity decreased in the order 5>8>7>6 as the position of substitution. Some of the compounds were also evaluated for protective effects against soman in mice. Several of the compounds have modest protective effects against 2LD50 soman. In the part of experimental materials, we found many familiar compounds, such as 2-Methylimidazo[1,2-a]pyridin-8-ol(cas: 79707-11-2Formula: C8H8N2O)
2-Methylimidazo[1,2-a]pyridin-8-ol(cas: 79707-11-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Formula: C8H8N2O
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem