The author of 《Label-free detection of exosomes using a surface plasmon resonance biosensor》 were Sina, Abu Ali Ibn; Vaidyanathan, Ramanathan; Wuethrich, Alain; Carrascosa, Laura G.; Trau, Matt. And the article was published in Analytical and Bioanalytical Chemistry in 2019. Quality Control of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid The author mentioned the following in the article:
The development of a sensitive and specific detection platform for exosomes is highly desirable as they are believed to transmit vital tumor-specific information (mRNAs, microRNAs, and proteins) to remote cells for secondary metastasis. Herein, the authors report a simple method for the real-time and label-free detection of clin. relevant exosomes using a surface plasmon resonance (SPR) biosensor. The authors’ method shows high specificity in detecting BT474 breast cancer cell-derived exosomes particularly from complex biol. samples (e.g. exosome spiked in serum). This approach exhibits high sensitivity by detecting as low as 8280 exosomes/μL which may potentially be suitable for clin. anal. The authors believe that this label-free and real-time method along with the high specificity and sensitivity may potentially be useful for clin. settings. In addition to this study using 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid, there are many other studies that have used 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Quality Control of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid) was used in this study.
5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Quality Control of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid And it has been used for blocking endogenous biotin during immunohistology procedures.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem