In 2019,Clinical Chemistry and Laboratory Medicine included an article by Saenger, Amy K.; Jaffe, Allan S.; Body, Richard; Collinson, Paul O.; Kavsak, Peter A.; Lam, Carolyn S. P.; Lefevre, Guillaume; Omland, Tobjorn; Ordonez-Llanos, Jordi; Pulkki, Kari; Apple, Fred S.. Category: imidazoles-derivatives. The article was titled 《Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)》. The information in the text is summarized as follows:
Two interferences recently brought to the forefront as patient safety issues include hemolysis (Hb) and biotin (vitamin B7). The International Federation for Clin. Chem. Committee on Cardiac Biomarkers (IFCC-CB) obtained input from a majority of cTn and NP assay manufacturers to collate information related to high-sensitivity (hs)-cTnI, hs-cTnT, contemporary, and POC cTn assays, and NP assays interferences due to hemolysis and biotin. The information contained in these tables was designed as educational tools to aid laboratory professionals and clinicians in troubleshooting cardiac biomarker anal. results that are discordant with the clin. situation. The results came from multiple reactions, including the reaction of 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5Category: imidazoles-derivatives)
5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid(cas: 58-85-5) may be used to elute proteins from avidin/streptavidin resins. It has been used for culturing of oligodendrocytes.Category: imidazoles-derivatives The biotin/avidin or biotin/streptavidin interaction is utilized in many labeling and purification schemes.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem