In 2022,Raghu, M. S.; Pradeep Kumar, C. B.; Yogesh Kumar, K.; Prashanth, M. K.; Alshahrani, Mohammad Y.; Ahmad, Irfan; Jain, Ranjana published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents》.Related Products of 7720-39-0 The author mentioned the following in the article:
To explore effective antituberculosis agents, a new class of imidazoles and benzimidazoles linked ethionamide analogs I [R = 1H-imidazol-2-yl, 1-methyl-1H-imidazol-2-yl, 1H-1,3-benzodiazol-2-yl, etc.] were designed and synthesized. The elemental anal., 1H NMR, 13C NMR and mass spectral data were used to characterize all of the novel analogs I. In vitro activity against Mycobacterium tuberculosis (Mtb) H37Rv was assessed for all of the target compounds I. The hydroxy and nitrile moieties on the imidazole ring, as well as the hydroxy and methoxy groups on the benzimidazole ring connected to the ethionamide side chain, were shown to be advantageous. In our cell viability experiment against the Vero cell line, all of the compounds I were non-cytotoxic even at 100μM. To confirm the powerful analogs target identification, their in vitro inhibitory action was investigated on an M. tuberculosis InhA over-expressing (Mtb InhA-OE) strain, which yielded MICs nearly twice those of the Mtb H37Rv strain. Furthermore, the results of mol. docking confirmed the exptl. findings. Addnl., the mols. were evaluated in silico for ADMET and drug similarity features. The exptl. observation enables the newly generated ethionamide derivatives to be attractive candidates for the creation of newer and better anti-TB agents. In the experimental materials used by the author, we found 1H-Imidazol-2-amine(cas: 7720-39-0Related Products of 7720-39-0)
1H-Imidazol-2-amine(cas: 7720-39-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Related Products of 7720-39-0
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem