In 2018,Archiv der Pharmazie (Weinheim, Germany) included an article by Keeley, Aaron; Abranyi-Balogh, Peter; Hrast, Martina; Imre, Timea; Ilas, Janez; Gobec, Stanislav; Keseru, Gyoergy M.. Electric Literature of C3H3BrN2. The article was titled 《Heterocyclic electrophiles as new MurA inhibitors》. The information in the text is summarized as follows:
An electrophilic fragment library of small heterocycles was developed and characterized in the surrogate GSH-reactivity assay and aqueous stability test that revealed their potential as covalent warheads. Screening the library against MurA from Staphylococcus aureus (MurASA) and Escherichia coli (MurAEC) identified heterocyclic fragments with significant inhibitory potency. The validated heterocyclic warhead library might be useful for developing targeted covalent inhibitors for other targets of interest with a new design strategy incorporating heterocyclic electrophiles as warheads. In addition to this study using 2-Bromo-1H-imidazole, there are many other studies that have used 2-Bromo-1H-imidazole(cas: 16681-56-4Electric Literature of C3H3BrN2) was used in this study.
2-Bromo-1H-imidazole(cas: 16681-56-4) is a member of imidazole. Its exclusive structural characteristics with enviable electron-rich features are favorable for imidazole-based fused heterocycles to bind efficiently with an array of enzymes and receptors in biological systems through various weak interactions like hydrogen bonds, ion-dipole, cation-π, π-π stacking, coordination, Van der Waals forces, hydrophobic effects, etc., and therefore they demonstrate widespread bioactivities. Electric Literature of C3H3BrN2
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem