《Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogs》 was published in Journal of Medicinal Chemistry in 1987. These research results belong to Kaminski, James J.; Hilbert, James M.; Pramanik, B. N.; Solomon, Daniel M.; Conn, David J.; Rizvi, Razia K.; Elliott, Arthur J.; Guzik, Henry; Lovey, Raymond G.. Related Products of 79707-11-2 The article mentions the following:
In search of a successor to the imidazol[1,2-a]pyridine I (X = CH, R = OCH2Ph, R1 = Me, R2 = CH2CN) (II) (Sch 28080), a compound that exhibits gastric antisecretory and cytoprotective properties, a series of imidazopyridines, e.g., I (X = CH; R = OCH2Ph; R1 = Me, NH2; R2 = Me, CH2CN, NH2) and of imidazopyrazines, e.g., I (X = N, R = OCH2Ph, R1 = Me, R2 = NH2) (III) were prepared In three of these potential successors of II, an amino group functions as a surrogate for the 3-cyanomethyl substituent of the prototype. In addition to an evaluation of the structure-activity relationships of a series of analogs of II, preliminary studies of the pharmacodynamics and metabolism of II were performed with the aid of cyano carbon labeled versions of the drug. II is well-absorbed and extensively metabolized; the major metabolite of II is the thiocyanate anion. A similar study performed on I (X = CH, R = OCH2Ph, R1 = Me, R2 = NH2) (IV), labeled at the 3-position with carbon-13 or carbon-14, revealed that IV, which has an antisecretory/cytoprotective profile comparable to that of II, is also metabolized to thiocyanate anion, although this must occur via a different mechanism. The potential sites of protonation of the pharmacol. similar IV and the structurally related imidazo[1,2-a]pyrazine III is discussed. Predictions based on charge d. and protonation product stabilities are presented. That N1 is the site of protonation in these analogs has been definitively demonstrated by x-ray crystal structure anal., which also unequivocally established the assigned imidazopyridine and imidazo[1,2-a]pyrazine ring structures.2-Methylimidazo[1,2-a]pyridin-8-ol(cas: 79707-11-2Related Products of 79707-11-2) was used in this study.
2-Methylimidazo[1,2-a]pyridin-8-ol(cas: 79707-11-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Related Products of 79707-11-2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem